Figure 2. Changes in Cardiovascular Disease Risk Discrimination and Classification After Adding Lipid-Related Markers.
The model containing conventional risk factors include age, systolic blood pressure, smoking status, history of diabetes, total and high-density lipoprotein cholesterol (HDL-C), each included as individual linear terms. Models were stratified by sex.
aNet reclassification improvement was calculated only for participants in studies with at least 10 years of follow-up. Change in C-index adding lipoprotein(a) greater than 30 mg/dL was 0.0001 (95% CI, −0.0001 to 0.0003).
bTriglyceride values were log-transformed.
cP<.05 for comparison against model containing conventional risk factors.
dP<.001 for comparison against model containing conventional risk factors.
eLipoprotein(a) was modeled nonlinearly by including linear and quadratic terms of log-transformed lipoprotein(a).