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. 2014 Oct 28;9(10):e110967. doi: 10.1371/journal.pone.0110967

Table 4. The differential expression of genes regulated by M. bicoloratus bracovirus in the host PI3K/Akt signaling pathway.

M/S
Gene family A_ID Function read_M RPKM_M read_S RPKM_S log2(Fold_change) normalized p-value Result S_ID M-ID
ATF4 comp93717_c0_seq1 CREB2; cyclic AMP-dependent transcription factor ATF-4 391 5.031431973 0.5 0.006665921 9.559949111 8.92893E-68 up / comp42406_c0_seq1
PEPCK comp109757_c0_seq1 phosphoenolpyruvate carboxykinase (GTP) 3834 27.16382297 574 4.213334979 2.688652009 0 up comp58069_c0_seq1 comp30301_c0_seq1
RP-S6e comp24289_c0_seq1 small subunit ribosomal protein S6e 1353 27.7189041 0.5 0.010612644 11.35087044 8.601E-176 up / comp11154_c0_seq1
COL4A comp23243_c0_seq1 type IV, alpha 33659 235.0626028 160548 1161.615892 −2.305016159 0 down comp45047_c0_seq1 comp10045_c0_seq2
CREB3 comp101801_c0_seq1 cyclic AMP-responsive element-binding protein 3 3995 24.04913606 11685 72.87636897 −1.599466012 0 down comp28212_c0_seq1 comp9969_c0_seq1
GSK3B comp23136_c0_seq1 glycogen synthase kinase 3 beta 1248 13.91068253 2965 34.2400086 −1.299489856 1.9348E-170 down comp47318_c0_seq1 comp20759_c0_seq2
HSP90B comp103187_c0_seq1 heat shock protein 90kDa beta 3701 23.9880501 9865 66.24426184 −1.465479601 0 down comp28148_c0_seq1 comp19950_c0_seq1
IRS1 comp97702_c0_seq2 insulin receptor substrate 1 268 2.200308994 696 5.920159847 −1.427929991 4.40292E-47 down comp58222_c1_seq1 comp53773_c0_seq1
ITGB1 comp107868_c0_seq1 integrin beta 1 2897 11.30115561 8616 34.82213249 −1.623534251 0 down comp46010_c0_seq2 comp20980_c0_seq2
LAMA3_5 comp99575_c0_seq1 laminin, alpha 3/5 27851 42.99292765 112433 179.8147605 −2.064340192 0 down comp59989_c0_seq1 comp17635_c0_seq1
LAMB1 comp95243_c0_seq1 laminin, beta 1 18108 49.24188678 51196 144.2366222 −1.550479569 0 down comp60102_c0_seq1 comp10145_c0_seq2
LAMC1 comp100060_c0_seq1 laminin, gamma 1 15999 40.61052537 52368 137.716847 −1.761779459 0 down comp60240_c0_seq1 comp10076_c0_seq1
PDPK1 comp89371_c0_seq4 3-phosphoinositide dependent protein kinase-1 1184 5.484101314 2310 11.08513688 −1.015299457 5.13123E-90 down comp57389_c0_seq3 comp19669_c0_seq2
PPP2C comp99514_c0_seq1 serine/threonine-protein phosphatase 2A catalytic subunit 4007 52.05795373 8123 109.3350776 −1.07056582 0 down comp134046_c0_seq1 comp24560_c0_seq1
PPP2R2 comp95673_c0_seq2 serine/threonine-protein phosphatase 2A regulatory subunit B 362 3.276611055 761 7.136352468 −1.122982442 1.08521E-35 down comp56391_c0_seq2 comp21423_c0_seq2
PPP2R5 comp25110_c0_seq1 serine/threonine-protein phosphatase 2A regulatory subunit B' 414 4.316267161 1061 11.46037093 −1.408797669 9.89141E-70 down comp226619_c0_seq1 comp18379_c0_seq1
PTEN comp97411_c0_seq4 PTEN 233 1.759294286 911 7.126499544 −2.018196785 5.8123E-99 down comp59211_c2_seq7 comp62639_c0_seq1
PTK2 comp89387_c1_seq2 focal adhesion kinase 1 1443 7.251236554 3747 19.50764073 −1.427740364 3.4416E-248 down comp58747_c0_seq2 comp20857_c0_seq2
RAC1 comp102261_c0_seq1 Ras-related C3 botulinum toxin substrate 1 4703 22.53778331 13189 65.48222111 −1.538757631 0 down comp61307_c0_seq1 comp211969_c0_seq1
STK11 comp68494_c0_seq3 serine/threonine-protein kinase 11 275 2.752794104 643 6.668487203 −1.276462805 6.66465E-37 down comp28880_c0_seq2 comp19353_c0_seq1
TSC2 comp93326_c0_seq1 tuberous sclerosis 2 42 1.079341152 227 6.043807401 −2.48530675 1.25293E-32 down comp31311_c0_seq1 comp76972_c0_seq1
YWHAE comp96021_c0_seq1 14–3-3 protein epsilon 55 1.03509774 357 6.960848804 −2.749496236 2.16594E-56 down comp58841_c0_seq1 comp18525_c1_seq1
AKT comp103304_c0_seq1 RAC serine/threonine-protein kinase 4590 25.54854119 8713 50.24541632 −0.975751075 0 comp62555_c0_seq1 comp30027_c0_seq1
ATF2 comp63925_c0_seq1 CREBP1; cyclic AMP-dependent transcription factor ATF-2 33 1.162462472 51 1.861274773 −0.679106908 0.041341344 comp30829_c1_seq1 comp100576_c0_seq1
BRCA1 comp95658_c0_seq1 breast cancer type 1 susceptibility protein 355 2.744122154 366 2.931105739 −0.09510031 0.409730291 comp54774_c0_seq1 comp10458_c0_seq1
CCND2 comp92629_c0_seq2 cyclin D2 1830 9.174971528 2968 15.41675056 −0.748723129 2.87139E-69 comp55005_c1_seq1 comp20586_c0_seq2
CCNE comp86772_c0_seq2 cyclin E 48 0.642601979 99 1.373128968 −1.095469805 1.62283E-05 comp29156_c0_seq1 comp130315_c0_seq1
CDC37 comp104439_c0_seq1 cell division cycle protein 37 1645 17.75049078 2932 32.77809747 −0.884873205 8.69703E-91 comp28183_c0_seq1 comp31800_c0_seq1
CDK4 comp93505_c0_seq2 cyclin-dependent kinase 4 91 1.026690365 248 2.898845626 −1.497477356 9.30914E-19 comp46659_c0_seq1 comp104770_c0_seq1
COL1AS comp140925_c0_seq1 type I/II/III/V/XI/XXIV/XXVII, alpha 0.5 0.035296871 59 4.315126435 −6.933718735 8.23218E-15 comp89703_c0_seq1 /
EGFR comp93202_c0_seq1 epidermal growth factor receptor 6514 18.3968606 6149 17.99184785 0.032116227 0.238280263 comp72419_c0_seq1 comp33128_c0_seq1
EIF4B comp103484_c0_seq1 translation initiation factor 4B 3735 23.01200087 6307 40.25890145 −0.806921376 7.4266E-166 comp45352_c0_seq1 comp9966_c0_seq1
EIF4E comp108936_c0_seq1 translation initiation factor 4E 671 7.905316174 1192 14.54950751 −0.88007525 2.69219E-37 comp38976_c0_seq1 comp18053_c0_seq1
EIF4EBP1 comp89898_c0_seq1 eukaryotic translation initiation factor 4E binding protein 1 78 2.176304201 0.5 0.01445341 7.234326533 3.10204E-18 / comp65767_c0_seq1
FGFR2 comp86525_c0_seq1 fibroblast growth factor receptor 2 9 0.147300349 80 1.35652114 −3.203078779 1.50516E-15 comp134334_c0_seq1 /
FRAP comp98229_c0_seq3 FKBP12-rapamycin complex-associated protein 501 1.205543964 1616 4.028672805 −1.740620375 3.1793E-143 comp57729_c1_seq1 comp19045_c1_seq1
G6PC comp92782_c0_seq1 glucose-6-phosphatase 2 0.039148868 87 1.764346079 −5.494019182 5.9857E-22 comp51802_c0_seq1 /
GBL comp96734_c0_seq1 G protein beta subunit-like 166 2.709305209 307 5.191149459 −0.9381311 1.47018E-11 comp45689_c0_seq2 comp52297_c0_seq1
GNB1 comp81476_c0_seq1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 7596 24.34298724 15821 52.52888221 −1.109604667 0 / comp20574_c0_seq1
GNB5 comp90181_c0_seq2 guanine nucleotide-binding protein subunit beta-5 337 4.024274883 558 6.903466944 −0.778592216 6.67432E-15 comp45009_c0_seq1 comp17886_c0_seq1
GNG13 comp95223_c0_seq1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 7200 46.4612554 8333 55.7102541 −0.261914759 6.81673E-29 comp61890_c0_seq1 comp24329_c0_seq1
GRB2 comp103695_c0_seq1 growth factor receptor-binding protein 2 4553 31.55832529 7467 53.62135235 −0.764786958 6.7036E-179 comp59056_c4_seq1 comp101386_c0_seq1
GYS comp95471_c0_seq2 glycogen(starch) synthase 96 0.657627746 591 4.194417817 −2.673127505 7.16393E-90 comp55945_c1_seq1 comp231427_c0_seq1
HSP90A comp23248_c1_seq1 molecular chaperone HtpG 30676 217.7778149 38447 282.7825966 −0.376836341 1.7963E-255 comp55995_c0_seq2 comp15914_c0_seq1
IKBKB comp46046_c0_seq1 inhibitor of nuclear factor kappa-B kinase subunit beta 628 4.037631507 887 5.908346682 −0.549245231 6.14389E-13 comp46039_c0_seq1 comp19169_c0_seq1
INSR comp97941_c0_seq7 insulin receptor 381 2.063839032 405 2.27290447 −0.139206596 0.201218987 comp55149_c2_seq1 comp9154_c1_seq1
JAK2 comp98009_c1_seq1 Janus kinase 2 407 1.908290622 691 3.356629968 −0.814732602 1.51786E-19 comp93258_c0_seq1 comp16460_c1_seq1
KRAS comp112119_c0_seq1 GTPase KRas 2904 11.39420805 3605 14.6544025 −0.363033492 2.01055E-23 comp46714_c0_seq1 comp37119_c0_seq1
MAP2K1 comp81191_c0_seq1 mitogen-activated protein kinase kinase 1 1619 6.495897191 2927 12.16719112 −0.905395446 3.63546E-94 comp174562_c0_seq1 comp20958_c0_seq1
MAPK1_3 comp23161_c0_seq1 mitogen-activated protein kinase 1/3 5679 21.44919695 7831 30.64302995 −0.514635322 3.1947E-93 comp28328_c0_seq1 comp9963_c0_seq1
MYB comp93622_c1_seq4 myb proto-oncogene protein 1093 4.733328627 1565 7.021601066 −0.568944942 2.91134E-23 comp58816_c0_seq6 comp9456_c0_seq2
MYC comp63425_c0_seq2 Myc proto-oncogene protein 2255 7.977064372 3204 11.74260281 −0.5578224 8.82957E-45 comp47218_c0_seq2 comp20721_c0_seq2
P110 comp97931_c0_seq1 phosphatidylinositol-4,5-bisphosphate 3-kinase, PIK3C 165 1.192085437 623 4.663229594 −1.967841825 6.96353E-66 comp56297_c1_seq1 comp85699_c0_seq1
P85 comp27492_c0_seq1 phosphoinositide-3-kinase, regulatory subunit, PIK3R 0.5 0.03906187 15 1.214086421 −4.957966281 0.000103715 comp39459_c0_seq1 /
PKN; comp67156_c0_seq1 protein kinase N 778 3.949050183 1366 7.183549165 −0.863191109 3.18306E-41 comp51044_c0_seq1 comp19192_c0_seq1
PPP2R1 comp101848_c0_seq1 serine/threonine-protein phosphatase 2A regulatory subunit A 4788 35.95160432 8113 63.11330498 −0.811888022 2.797E-215 comp28215_c0_seq1 comp10104_c0_seq1
PPP2R3 comp207060_c0_seq1 serine/threonine-protein phosphatase 2A regulatory subunit B 17 0.429343833 42 1.098957536 −1.355930267 0.000936344 comp141105_c0_seq1 /
PRKAA comp88394_c0_seq1 AMPK; 5′-AMP-activated protein kinase, catalytic alpha subunit 935 5.517046633 1081 6.608395875 −0.260403939 9.36228E-05 comp46858_c0_seq1 comp19779_c0_seq1
RAPTOR comp96751_c0_seq3 regulatory associated protein of mTOR 186 1.325822604 550 4.061724643 −1.615204683 1.12036E-44 comp28927_c0_seq2 comp85394_c0_seq1
RHEB comp94584_c0_seq1 Ras homolog enriched in brain 150 2.527973388 197 3.43971752 −0.444308815 0.006072962 comp83256_c0_seq1 comp65541_c0_seq1
RPS6KB comp110869_c0_seq1 p70 ribosomal S6 kinase 1391 8.265982996 2672 16.4505016 −0.992873274 3.286E-100 comp70041_c0_seq1 comp10389_c0_seq1
SOS comp96783_c0_seq11 son of sevenless 74 1.123281762 195 3.066669068 −1.448952634 2.40343E-14 comp47573_c1_seq1 comp17032_c1_seq1
THBS2S comp28902_c0_seq1 thrombospondin 2/3/4/5 31 0.720784511 15 0.361335244 0.996230029 0.029739095 comp378223_c0_seq1 /
TSC1 comp87058_c0_seq1 tuberous sclerosis 1 15 0.611757829 46 1.943665035 −1.667747046 5.20854E-05 comp30877_c0_seq1 /
YWHAB_Q_Z comp63845_c0_seq2 14-3-3 protein beta/theta/zeta 25941 59.75452622 34171 81.54871003 -0.448614059 0 comp45161_c0_seq1 comp17512_c0_seq2