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. 2014 Oct 28;9(10):e111334. doi: 10.1371/journal.pone.0111334

Figure 2. Schematic representation of epitope predictions in RV144 HIV-1 breakthrough sequences, and their comparison to RV144 vaccine inserts.

Figure 2

A. Each line represents the Env-gp120 sequence from a subject and each circle a CD8 epitope prediction (different colors for different HLA alleles). The figure represents epitopes predicted based on each subject’s HLA class I genotype for two subjects who were infected with a nearly identical virus (AA100: HLA-A*02∶03, HLA-A*24∶10, HLA-B*18∶01, HLA-B*18∶02, HLA-C*07∶04; AA118: HLA-A*11∶01, HLA-A*24∶07, HLA-B*44∶03, HLA-C*01∶02, HLA-C*07∶01). B. Epitope repertoires from a given subject are compared to the epitope predictions for the vaccine insert sequences (CM244 and MN) based on that subject’s HLA class I genotype. Empty circles represent epitopes predicted in the sequence from a subject that could not be matched to a corresponding epitope prediction based on the vaccine insert sequence and the subject’s HLA class I genotype. More subject-derived epitopes were matched against the vaccine insert CM244 than against MN; both subjects were infected by a CRF01-AE virus like CM244, while MN is a subtype B virus.