Figure 7. Correlation of IgM levels and treatment efficacy.

(A) IgM level in the sera of BALB/c mice collected 8 days post i.n. infection with 18 LD₅₀ of ECTV was determined by ELISA. Survival proportions of each group are designated above each bar. Asterisk denote for significant difference compared to the infected untreated group (P<0.01, n = 6 in the infected untreated group, n = 3 in the treated groups, t-test). Dotted line represent limit of detection. (B) Correlation between IFNγ and IgM levels of the mice presented in panel A. Green circles - examined mice from groups in which the survival rate was 50% and above. Red triangles - examined mice from groups in which the survival rate was less than 50%. R² value represents a non-linear fit.