Figure 2.

Representative image of immunohistological assay for NF-κB (p65) in the ischemic penumbra tissues of rats. Flurbiprofen inhibits translocation of NF-κB into the nucleus induced by ischemia/reperfusion. In ischemia/reperfusion and vehicle groups, the expression of NF-κB (p65) (brown staining) in ischemic penumbra was detected by immunohistological assay after 24 hours of reperfusion. NF-κB (p65) predominantly located in the nucleus, whereas flurbiprofen can significantly inhibit its translocation from cytoplasm into the nucleus. Magnification, 400×.