Table 4.
Summary of quality classification for studies of predictive factors in advanced non-small-cell lung cancer
| Performance status | Disease stage | Sex | Age | Histology | Race | Previous therapya | Smoking | Laboratory value variables | |
|---|---|---|---|---|---|---|---|---|---|
| PRED-2 studies | |||||||||
| Ardizzoni et al63 | – | – | – | – | ● | – | – | – | – |
| Itaya et al52 | – | – | – | – | ○ | – | – | ○ | – |
| Obasaju et al64 | – | – | – | – | – | ○ | – | – | – |
| Scagliotti et al28 | – | – | – | – | ○ | – | – | – | – |
| Soria et al65 | ●b | – | – | – | – | – | – | – | ○ |
| Syrigos et al66 | ● | ● | – | ● | ● | ● | – | ● | – |
| Teramukai et al30 | – | – | – | – | – | – | – | – | ○ |
| PRED-3 studies | |||||||||
| Sculier et al41 | – | – | ● | ● | – | – | – | – | – |
| Wakelee et al31 | – | – | ○ | – | – | – | – | – | – |
| PRED-4 studies | |||||||||
| Goto et al62 | – | – | – | – | – | – | ● | – | – |
Notes: PRED-2–4 represents a rating system for predictive studies where two is high and four is low. ○ indicates a variable considered in the analysis. • indicates a variable significant in the analysis. – indicates a variable not mentioned in the reporting.
a
Response to previous therapy, type of previous therapy, or interval between lines of therapy in second-line or later line of treatment.
b
Borderline significant interaction.