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. Author manuscript; available in PMC: 2014 Oct 28.
Published in final edited form as: R I Med J (2013). 2014 Feb 3;97(2):35–37.

Figure 1. A possible mechanism and marker for diastolic dysfunction.

Figure 1

Hypertension and diabetes lead to cardiac oxidation and S-glutathionylation of cardiac myosin binding protein-C (MyBP-C), a cardiac contractile protein. This leads to impaired relaxation, and modified MyBP-C in the blood may represent a biomarker for diastolic dysfunction.