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. 2014 Oct 28;9(10):e111076. doi: 10.1371/journal.pone.0111076

Figure 8. Loss of Olig3 function does not obviously affect the development of V2 and V3 interneurons and motor neurons.

Figure 8

Spinal cord sections from E13.5 wild-type (A, C, E) and Olig3−/− (B, D, F) embryos were subjected to immunostaining with anti-Chx10 (A, B), anti-Nkx2.2 (C, D) and anti-Islet1 (E, F). The production and distribution of these interneurons was similar in wild-type and Olig3−/− spinal cords. Loss of Olig3 didn’t affect the generation of motor neurons, but inhibited the production of Islet1+dI3 interneurons. (G) The ratio of positive cells in Olig3−/− spinal cords compared to wild type. p>0.05. The dorsal part is up. Bars, 100 µm.