Fig. 3.

Interface between SIRT1^CAT and the C-terminal regulatory segment. Ribbon representation of the interface between the SIRT1^CAT and the CTR colored according to Fig. 1a. The inset illustrates the position of the CTR-binding site on the larger NAD⁺-binding domain and its interacting residues and is expanded on the right. Residues participating in the interface are shown in ball-and-stick representation.