Table 2.

Analysis of risk factors for nephrotoxicity

Univariable Analysis
Variable	Odds Ratio	95% Confidence Interval
Guideline-recommended vancomycin dosing	0.95	0.40–2.28
Patient age of 80 years or greater	0.37	0.12–1.17
Vancomycin trough > 15 mg/l	1.77	0.73–4.27
Vancomycin area under the curve ≥ 400 mg*hr/L	0.57	0.23–1.40
Vancomycin duration of 15 days or greater	2.16	0.88–5.30
Charlson comorbity index > 5	1.28	0.37–4.52
Pitt bacteremia score of 4 or greater	4.88	1.79–13.26
Intensive care unit residence	5.83	2.12–15.89
Concomitant nephrotoxins (aminoglycosides, intravenous contrast and vasopressors)	2.84	1.16–6.98
Weight of 100kg or greater	0.96	0.29–3.26
Multivariable Analysis
Guideline-recommended vancomycin dosing	1.13	0.40–3.19
Patient age of 80 years or greater	0.53	0.14–2.03
Pitt bacteremia score of 4 or greater	2.71	0.88–8.32
Intensive care unit residence	3.58	1.15–11.09
Concomitant nephrotoxins (aminoglycosides, intravenous contrast and vasopressors)	1.71	0.60–4.82