Table 3.

Analysis of risk factors for in-hospital mortality

Univariable Analysis
Variable	Odds Ratio	95% Confidence Interval
Guideline-recommended vancomycin dosing	1.01	0.40–2.54
Vancomycin trough > 15 mg/l	1.06	0.42–2.65
Vancomycin duration of 15 days or greater	1.40	0.55–3.58
Vancomycin area under the curve ≥ 400 mg*hr/L	0.74	0.29–1.93
Charlson comorbity index > 5	0.60	0–2.68
Pitt Bacteremia Score of 4 or greater	3.33	1.22–9.14
Intensive care unit residence	7.14	2.28–22.08
Concomitant nephrotoxins (aminoglycosides, intravenous contrast and vasopressors)	1.69	0.67–4.25
Development of nephrotoxicity	1.84	0.71–4.79
Weight of 100kg or greater	0.47	0.00–2.08
Patient age of 80 years or greater	1.00	0.35–2.86
Multivariable Analysis
Guideline-recommended vancomycin dosing	1.14	0.41–3.18
Pitt bacteremia score of 4 or greater	1.90	0.59–6.08
Development of nephrotoxicity	0.80	0.25–2.52
Intensive care unit residence	6.39	1.78–22.93