Table 1. Characteristics of membrane properties of rat cerebellar DCN neurons aged between p16 and p40.
Groups | N | Resting Vm (mV) |
Spontaneou sly firing frequency (Hz) |
Input resistance (MΩ) |
Threshold (mV) |
Current required for elicited AP |
Latency for 1st elicited AP (ms) |
AP amplitude (mV) |
APD (ms) | APD rising phase(ms) |
APD falling phase (ms) |
AHP (mV) | S1S2(ms) | S2S3 (ms) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-weaning (p16-21) | 25 | -48.40±0.72 | 14.33±1.77 | 112.32 ±8.35 | -46.29±0.79 | 0.04±0.01 | 20.05±2.26 | 61.74±1.86 | 1.09±0.10 | 0.42±0.03 | 0.68±0.07 | -7.26±1.04 | 11.45±1.46 | 16.66±2.46 |
Post-weaning (p22-40) | 59 | -48.93±0.46 | 20.04±2.19 | 108.11 ±5.20 | -45.38±0.58 | 0.04±0.01 | 24.27±3.29 | 61.12±1.32 | 0.87±0.04* | 0.36±0.01* | 0.51±0.02** | -12.00±0.51*** | 19.39±2.23* | 22.64±2.27 |
Vm: membrane potential; AP: Action potential; APD: action potential duration; AHP: afterhyperpolarization.
P<0.05 between Pre-weaning and Post-weaning group,
P<0.01,
P<0.001