Table 2.

Longitudinal association of PROMIS-F T scores with mitochondrial related gene expression using a GEE model with adjustment for age, baseline hemoglobin, and time varying depression

	Parameter
	Intercept		Time		Gene		Time*Gene		Age		Depression		Hb
Gene	Coef	p-val	Coef	p-val	Coef	p-val	Coef	p-val	Coef	p-val	Coef	p-val	Coef	p-val
AIFM2	57.64	0.0002	0.04	0.8409	−0.33	0.5394	0.01	0.8119	−0.15	0.2152	0.46	0.0045	−0.05	0.9616
BCL2	57.09	0.0001	0.04	0.7564	−0.34	0.6098	0.01	0.7021	−0.15	0.1675	0.46	0.0040	−0.06	0.9541
BCL2L1	53.96	0.0006	0.04	0.1205	−1.61	0.0063*	0.03	0.0304	−0.13	0.2389	0.45	0.0093	0.08	0.9374
BCS1L	45.82	0.0038	0.27	0.0870	1.34	0.0066*	−0.03	0.1383	−0.14	0.2533	0.47	0.0030	−0.06	0.9549
BNIP3	61.43	0.0001	−0.04	0.7221	−0.88	0.2596	0.02	0.2579	−0.14	0.2242	0.48	0.0028	−0.15	0.8833
COX6B1	55.52	0.0006	0.10	0.2804	0.11	0.8720	−0.01	0.7279	−0.16	0.1726	0.45	0.0092	−0.06	0.9566
FIS1	56.70	0.0004	−0.02	0.6540	−2.03	0.0148*	0.04	0.0243	−0.11	0.3359	0.42	0.0135	−0.00	0.9977
FXC1	57.80	0.0001	−0.01	0.9118	−0.41	0.5742	0.02	0.3925	−0.16	0.1702	0.46	0.0055	−0.06	0.9551
IMMP2L	55.97	0.0002	0.05	0.7108	0.18	0.8128	0.00	0.8554	−0.17	0.1194	0.43	0.0060	−0.04	0.9669
MIPEP	58.23	0.0005	0.04	0.7728	−0.29	0.6759	0.01	0.7429	−0.15	0.1657	0.45	0.0109	−0.10	0.9201
SLC25A21	63.32	<.0001	−0.13	0.5061	−0.62	0.3045	0.02	0.3308	−0.15	0.1857	0.40	0.0154	−0.04	0.9696
SLC25A23	57.02	0.0001	0.00	0.9907	−0.02	0.9790	0.01	0.5719	−0.17	0.1557	0.44	0.0046	−0.07	0.9483
SLC25A37	49.44	0.0026	0.10	0.0097	−2.31	0.0008*	0.04	0.0032	−0.12	0.3122	0.45	0.0059	0.08	0.9314
SLC25A4	55.58	0.0003	0.13	0.5247	0.03	0.9473	−0.01	0.7744	−0.15	0.1923	0.44	0.0055	−0.07	0.9497

Coef. = Coefficient, p-val = p-value, PROMIS-F = Patient Reported Outcomes Measurement Information System-Fatigue subscale, GEE = generalized estimating equation.

^*Gene expression was significantly associated with PROMIS-F T-scores (p < .05).