. Author manuscript; available in PMC: 2015 Nov 1.

Published in final edited form as: Br J Haematol. 2014 Aug 12;167(4):500–505. doi: 10.1111/bjh.13067

Table II.

Univariate and Multivariate analysis of factors predicting worse overall

Variable	Overall survival
	Univariate		Multivariate
	HR (95% CI)	P - value	HR (95% CI)	P - value
≥100 clonal cPCs detected	3.32 (2.05 - 5.41)	< 0.0001	2.67 (1.37 - 5.17)	0.0041
Number of prior lines of therapy	1.15 (1.05 - 1.26)	0.0027	4.09 (1.56 - 10.14)	0.0048
Serum creatinine	1.56 (1.23 - 1.88)	0.0008	1.29 (0.89 - 1.87)	0.1723
β2-microglobulin	1.12 (1.07 – 1.16)	< 0.0001	1.05 (0.97 - 1.12)	0.2165
Elevated LDH (> 222 u/l)	1.02 (1.01 – 1.03)	< 0.0001	2.93 (1.67 - 5.08)	0.0003
High bone marrow PC%	1.00 (0.99 - 1.02)	0.0785	-	-
High risk status by FISH	1.64 (0.88 - 2.95)	0.1138	-	-

survival

Bolded P-values and HRs represent statistically significant variables (i.e. P < 0.05)

cPCs, circulating plasma cells; LDH, lactate dehydrogenase; PC%, plasma cell percentage; FISH, fluorescent in-situ hybridization; HR, Hazard ratio; 95% CI, 95% confidence interval.