Table 1.
Subject characteristics and risk factor prevalence according to the rs2453021 genotype in IMPROVE.
| Genotype | ||||
|---|---|---|---|---|
|
|
||||
| CC | CT | TT | P | |
| n | 1,517 | 1,510 | 391 | |
| Subject characteristics | ||||
| Male sex (%) | 48.4 | 47.9 | 48.3 | 0.888 |
| Age (years) [mean (95% CI)] | 64.4 (64.2–64.7) | 64.0 (63.8–64.3) | 64.1 (63.6–64.7) | 0.091 |
| BMI (kg/m2) [mean (95% CI)] | 27.2 (27.0–27.4) | 27.3 (27.1–27.5) | 27.1 (26.7–27.5) | 0.859 |
| CRP (mg/L) [median (IQR)] | 1.86 (0.74–3.67) | 1.86 (0.78–3.53) | 1.86 (0.80–3.58) | 0.719 |
| Risk factors | ||||
| Hypercholesterolemia (%) | 68.3 | 69.7 | 76.2 | 0.008 |
| Hypertriglyceridemia (%) | 23.7 | 28.2 | 27.6 | 0.012 |
| Hypoalphalipoproteinemia (%) | 12.5 | 13.7 | 14.1 | 0.308 |
| Hypertension (%) | 70.6 | 67.3 | 68.3 | 0.122 |
| Diabetes (%) | 27.9 | 26.1 | 24.2 | 0.114 |
| Family history of peripheral vascular disease (%) | ||||
| No | 79.5 | 77.4 | 81.3 | 0.435 |
| Yes | 11.0 | 13.2 | 11.0 | |
| Not known | 9.6 | 9.4 | 7.7 | |
| Family history of cerebrovascular disease (%) | ||||
| No | 60.3 | 61.2 | 59.8 | 0.902 |
| Yes | 35.2 | 35.3 | 36.1 | |
| Not known | 4.6 | 3.6 | 4.1 | |
| Family history of coronary heart disease (%) | ||||
| No | 32.9 | 35.1 | 34.3 | 0.389 |
| Yes | 63.2 | 61.6 | 62.4 | |
| Not known | 3.8 | 3.2 | 3.3 | |
| Current smoker (%) | 16 | 15.2 | 9.5 | 0.006 |
| Smoking pack-year category (%) | ||||
| Never smoker | 48.4 | 49.6 | 50.4 | 0.234 |
| 1st quartile | 12.3 | 12.3 | 14.9 | |
| 2nd quartile | 13.8 | 11.9 | 12.1 | |
| 3rd quartile | 11.9 | 13.4 | 10.8 | |
| 4th quartile | 13.6 | 12.9 | 11.8 | |
P values are from linear regression and χ2 tests for linear-by-linear association. Dyslipidemia was defined as hypercholesterolemia (mean calculated LDL cholesterol levels >160 mg/dL or treatment with lipid-lowering drugs), hypertriglyceridemia (triglyceride levels >200 mg/dL or treatment with triglyceride-lowering drugs) and hypoalphalipoproteinemia (HDL cholesterol <40 mg/dL). Hypertension was defined as diastolic blood pressure >90 mmHg and/or systolic blood pressure >140 mmHg or treatment with antihypertensive drugs. Diabetes was defined as fasting glucose level >126 mg/dL (7.0 mmol/L) or treatment with insulin or oral hypoglycemic drugs (20). IQR, interquartile range. Genotype: CC, homozygote major C allele; CT, heterozygote; TT, homozygote minor T allele.