Table 1.

SPM results for main effect of cue intensity^a

Cluster	Region	k	x	y	z	Z-score	Context effect	Model evidence
1	Left mid-insula	1519	−34	−2	14	5.4*	−0.6	0.83
	Left posterior insula		−36	−20	18	4.9*	−0.6	0.97
	Left parietal operculum/posterior insula		−54	−32	24	4.1	0.0	0.93
2	Left mid-cingulate gyrus	2887	−12	−2	44	5.4*	−0.3	0.84
	Left cingulate sulcus, marginal segment		−14	−40	48	4.8*	0.1	0.99
	Right mid-cingulate/posterior cingulate		6	−16	44	4.3	−0.4	0.97
	Anterior cingulate		0	34	18	4.2	0.7	0.83
3	Right mid-insula	1827	34	8	12	4.6**	0.4	0.63
	Right inferior mid-insula		38	−2	−12	4.5**	0.9	0.81
	Right posterior insula		40	−14	0	4.5**	−0.5	0.93
	Right anterior insula		48	16	−6	3.9	0.1	0.83
4	Right inferior frontal gyrus	166	42	24	16	4.6**	2.0	0.99
5	Left intraparietal sulcus	180	−36	−62	44	4.4	0.1	>0.99
6	Left middle temporal gyrus	94	−56	−64	4	4.0	0.9	0.99
7	Left postcentral gyrus	86	−30	−28	58	4.0	−0.4	0.88
8	Right thalamus	55	8	−2	6	3.5	0.8	0.75
9	Right middle frontal gyrus	29	50	8	46	3.5	−0.8	0.99
10	Thalamus	21	0	−16	10	3.3	0.3	0.77
11b	Right parieto-occipital fissure	499	8	−74	36	4.5	2.1	0.99
	Left parieto-occipital fissure		−10	−74	34	4.4	3.3	0.99
12b	Left central sulcus	83	−34	−20	42	3.8	0.9	0.50
13b	Left postcentral gyrus	25	−58	−40	46	3.8	−0.8	0.72
14b	Left precentral gyrus	30	−40	−2	50	3.7	0.4	0.55
15b	Right superior temporal sulcus	37	56	−52	12	3.6	0.2	0.98
16b	Right intraparietal sulcus	37	36	−54	48	3.6	0.3	0.96
17b	Right superior precentral sulcus	52	46	−6	50	3.4	−0.2	0.90
18b	Left anterior calcarine sulcus	36	−14	−58	4	3.4	2.4	0.81
19b	Right postcentral gyrus	29	16	−34	70	3.4	−1.0	0.96

^aSPMs inspected at p < 0.001 uncorrected, minimum cluster size of 20 contiguous voxels. Peaks of clusters 1–10 fall within the mask used for SVC for this contrast (derived from a meta-analysis of pain-related studies).

^bRemaining clusters fell outside this mask. Cluster size (k) refers to total cluster size (i.e., including voxels outside the mask where the peak falls within). “Context effect” is the z-score for the simple effect of context on medium intensity cues (medium in the context of low to medium in the context of high). “Model evidence” refers to a random effects model comparison of intensity-processing and rank-processing models, reflecting the posterior probability favoring an intensity-processing model over a rank-processing model. No peak voxels within the key regions of interest show a significant context effect, and no region shows a posterior probability favoring the rank-processing model.

*p < 0.05, corrected for multiple comparisons across entire brain volume.

**p < 0.05, corrected for multiple comparisons across small volume of interest.