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. 2014 Oct 29;34(44):14560–14570. doi: 10.1523/JNEUROSCI.1310-14.2014

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Copyright © 2014 the authors 0270-6474/14/3414560-11$15.00/0

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Figure 2. — α₁-Adrenergic receptors mediate the PHE-LTD. A, Blockade of α₁-ARs with prazosin (10 μm) abolishes the PHE-LTD. Left, Summary graph of the PHE-LTD in control condition (white circles, n = 8) and in the presence of prazosin (10 μm, filled red circles, n = 8). Right, Superimposed EPSC traces taken at the time points indicated by numbers in the left panel. B, The PHE-LTD is not caused by persisting stimulation of α₁-ARs. Left, Summary graph of the PHE-LTD obtained during washout of PHE with prazosin. Right, Superimposed EPSC traces collected during the time point indicated by numbers in the left panel. Calibration: 50 pA, 10 ms.