Figure 3.

The α₁-AR LTD is mediated by a decrease in glutamate release. A, Summary graph of the α₁-AR LTD recorded using a pair of stimuli with an interstimulus interval of 30 ms (n = 7). Left, Superimposed EPSC traces (average of 60 trials) collected before (1) and (2) during the α₁-ARs LTD. B, α₁-AR LTD is accompanied by a persistent and significant increase in PPR (n = 7). C, Summary histogram of average PPR obtained in baseline condition and during LTD (n = 7). *p < 0.05. D, Change in 1/CV² as a function of EPSC amplitude. α₁-AR LTD is associated with a significant increase in the CV (n = 7). *p < 0.05. Calibration: 50 pA, 20 ms.