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. 2014 Oct 29;34(44):14560–14570. doi: 10.1523/JNEUROSCI.1310-14.2014

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Copyright © 2014 the authors 0270-6474/14/3414560-11$15.00/0

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Figure 7. — Exposure to CRS impairs the function of presynaptic CB1 receptors in the DRn. A, CRS reduces the ability of presynaptic CB1 receptors to inhibit glutamate release. Top, Superimposed AMPA-EPSCs taken before and during bath application of the CB1 receptor agonist WIN 55212-2 (10 μm) in control (left) and CRS-exposed rats (right). Calibration: 50 pA, 10 ms. Bottom, Summary graph of the inhibition of AMPA-EPSC amplitude induced by WIN 55212-2 (10 μm) in control (white circles, n = 13) and CRS-exposed rats (red circles, n = 10). CRS exposure profoundly reduces the efficacy of WIN 55212-2 in inhibiting the amplitude of AMPAR-EPSCs. B, Dose–response curves of the effect of WIN 55212-2 on AMPAR-EPSCs obtained in control (white circles) and CRS-exposed rats (red circles). **p < 0.01. C, Exposure to CRS profoundly reduces the magnitude of the eCB-mediated DSE. Left, DSE induced in control (white circles, n = 14) and CRS-exposed rats (red circles, n = 12). Right, Superimposed AMPAR-EPSCs traces taken before and during the DSE in putative DRn 5-HT neurons from control and CRS-exposed rats. Calibration: 50 pA, 10 ms.