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. 2014 Oct 14;12:84. doi: 10.1186/s12915-014-0084-2

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© Assmann et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Diminazene is a potent inhibitor of HyNaCs. A) Current trace illustrating the concentration-dependent inhibition of HyNaC2/9/7 by diminazene. Block by 100 μM amiloride was used to compare the affinity for diminazene and amiloride. Note that current amplitude transiently increased after washout of the blockers. Dashed lines represent the zero current level. B) Concentration-response curves showing the concentration-dependent inhibition of HyNaCs by diminazene. HyNaCs, Hydra Na⁺ channels.