Figure 2.

Sequence alignment of HyNaC2 – HyNaC12 with ASIC1a and BASIC. HyNaCs share conserved motifs and structures that are typical for DEG/ENaCs. Conserved amino acids are highlighted as white letters on black background. Bars indicate the putative position of TMDs and circles conserved cysteines in the ECD. The selectivity filter in TMD2 is indicated by an ellipse and the conserved N-terminal HG motif by an open bar. Accession numbers can be found in the legend to Figure 1. ASIC, acid-sensing ion channel; BASIC, bile-acid sensitive ion channel; ECD, extracellular domain; HyNaC, Hydra Na⁺ channel; TMDs, transmembrane domains.