Figure 9.

Anti- Wolbachia activity against Onchocerca macrofilariae in SCID mice. (A)% recoveries, (B) Wolbachia loads per motile male Onchocerca macrofilaria measured by wsp gene copy number or (C) Wolbachia loads per motile male Onchocerca macrofilaria as a ratio wsp/gst filarial gene copy number +29 days after intraperitoneal implantation in CB.17 SCID mice and +28 days after commencement of 2 week oral 15 mg/kg rifapentine (RIFAP) or vehicle control (VC). Error bars indicate median and interquartile range. Dashed horizontal lines indicate 1 and 2 log reductions compared with median VC levels. Median % reduction is indicated in parentheses. For B&C, data from individual worms are pooled from groups of two mice. Significant differences between groups (Mann Whitney Test) are indicated ***P < 0.001.