Figure 6.

Radiosensitization of SK28 tumors by DT01 with a “radical” RT protocol. Mice bearing subcutaneous SK28 melanoma tumor xenografts were untreated (NT), treated for 4 weeks with 10 fractions of 3 Gy (RT_4w), or treated with combined RT and DT01 treatments (RT_4w + DT01_4w). (A) Treatment schedule. Each RT 3-Gy fraction is represented by a black triangle. Each DT01 4-mg local administration is represented by a gray triangle. (B) Tumor growth. DT01 with RT significantly increased tumor growth control. (C) Survival. Mice were monitored until tumors reached 1500 mm³ (death time). Survival was significantly improved in mice treated with RT_4w + DT01_4w. V_t, tumor volume at a given time point; V_i, initial volume before treatment.