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Model of the role of CK2 phosphorylation and inhibition of TAp73 in CSC gene program and phenotype. CK2 theonine/serine kinase mediates phosphorylation and inactivation of tumor suppressor TAp73, promoting expression of CSC genes and phenotype. CK2 inhibition by small molecule inhibitors DMAT or CX-4945, or T27A mutation of the CK2 phosphoacceptor motif of TAp73 uncovers TAp73 as a suppressor of CSC genes and phenotype.
