Methods | Patients were assigned to desmopressin or placebo according to a randomisation schedule. The method used to generate allocation sequences was not described. Study solutions were prepared by a research pharmacist | |
Participants | 65 patients pre-treated with aspirin within 7 days before scheduled elective coronary artery bypass graft surgery were randomised to one of two groups
NB: Six patients were excluded from the analysis, three from the DDAVP group and three from the placebo group (two died intra-operatively, one inadvertently received DDAVP, and three required the insertion of an intra-aortic ballon pump) |
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Interventions |
NB: Both groups were exposed to cell salvage. |
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Outcomes | Number of patients transfused allogeneic blood (n) Amount of allogeneic blood transfused (units) Fresh frozen plasma (units) Platelets (units) Blood loss (ml) Mortality (n) Non-fatal myocardial infarction (n) Arrhythmia (n) Encephalopathy (n) |
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Notes | Quality assessment score (Schulz criteria): 5/7 Transfusion protocol not specified. |
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Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Unclear | Method of randomisation was not described. |
Allocation concealment? | Yes | A - Adequate |
Blinding? All outcomes |
Yes | Double blind. |