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. Author manuscript; available in PMC: 2014 Oct 29.
Published in final edited form as: Cochrane Database Syst Rev. 2004;(1):CD001884. doi: 10.1002/14651858.CD001884.pub2
Methods Patients were assigned to either treatment or placebo groups using a computer-generated random-number table. The method used to conceal treatment allocation was not described
Participants 62 patients undergoing elective coronary artery bypass grafting were randomised to one of two groups
  1. Desmopressin (DDAVP) group: n = 31; mean age (+/−SD) = 61 (10) years.

  2. Placebo group: n = 31; mean age (+/−SD) = 59 (9) years.

Interventions
  1. DDAVP group received 100 ml saline containing 0.3 ug/kg of desmopressin infused over 15 minutes immediately after the administration of protamine sulfate.

  2. Placebo group received 100 ml saline infusion over 15 minutes immediately after the administration of protamine sulfate.

Outcomes Number of patients transfused allogeneic blood transfusion (n)
Amount of allogeneic blood transfused (units)
Blood loss (ml)
Mortality (n)
Myocardial infarction (n)
Re-operation for bleeding (n)
Notes Quality assessment score (Schulz criteria): 4/7
Transfusion protocol not used.
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Yes Patients were assigned to either treatment or placebo groups using a computer-generated random-number table
Allocation concealment? Unclear B - Unclear
Blinding?
All outcomes
Yes Double blind.