Methods	Patients were assigned to either treatment or placebo groups using a computer-generated random-number table. The method used to conceal treatment allocation was not described
Participants	62 patients undergoing elective coronary artery bypass grafting were randomised to one of two groups Desmopressin (DDAVP) group: n = 31; mean age (+/−SD) = 61 (10) years. Placebo group: n = 31; mean age (+/−SD) = 59 (9) years.
Interventions	DDAVP group received 100 ml saline containing 0.3 ug/kg of desmopressin infused over 15 minutes immediately after the administration of protamine sulfate. Placebo group received 100 ml saline infusion over 15 minutes immediately after the administration of protamine sulfate.
Outcomes	Number of patients transfused allogeneic blood transfusion (n) Amount of allogeneic blood transfused (units) Blood loss (ml) Mortality (n) Myocardial infarction (n) Re-operation for bleeding (n)
Notes	Quality assessment score (Schulz criteria): 4/7 Transfusion protocol not used.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	Patients were assigned to either treatment or placebo groups using a computer-generated random-number table
Allocation concealment?	Unclear	B - Unclear
Blinding? All outcomes	Yes	Double blind.