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. Author manuscript; available in PMC: 2014 Oct 29.
Published in final edited form as: Cochrane Database Syst Rev. 2004;(1):CD001884. doi: 10.1002/14651858.CD001884.pub2
Methods Methods of randomisation and allocation concealment were not described
Participants 50 patients scheduled for aorto-iliac graft surgery were randomly allocated to one of two groups

  1. Desmopressin (DDAVP) group: n = 25; M/F = 19/6.

  2. Placebo group: n = 25; M/F = 18/7.


NB: Age data were not reported.
Interventions

  1. DDAVP group received 0.3 ug/kg of DDAVP diluted in physiological saline to a volume of 10 ml and injected intravenously over 10 minutes immediately before the start of the operation.

  2. Placebo group received 10 ml of physiological saline injected intravenously over 10 minutes immediately before the start of the operation.


NB: Both groups received 500 ml of dextran 40 (Rheomacrodex) as thromboprophylaxis
Outcomes Amount of allogeneic blood transfused (units)
Blood loss (ml)
Myocardial infarction (n)
Notes Quality assessment score (Schulz criteria): 3/7
Transfusion protocol used.
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Method of randomisation was not described.
Allocation concealment? Unclear B - Unclear
Blinding?
All outcomes		 Yes Double blind.