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. Author manuscript; available in PMC: 2014 Oct 29.
Published in final edited form as: Cochrane Database Syst Rev. 2004;(1):CD001884. doi: 10.1002/14651858.CD001884.pub2
Methods Methods of randomisation and allocation concealment were not described
Participants 20 patients scheduled to undergo elective CABG surgery were randomised in double-blind fashion to one of two groups

  1. Desmopressin (DDAVP) group: n = 10; M/F = 8/2; mean age (+/−SD) = 61.7 (8.1) years.

  2. Placebo group: n = 9; M/F = 6/3; mean age (+/−SD) = 62.5 (6.9) years.
Interventions

  1. DDAVP group received 0.3 ug/kg intravenously (IV) over a 10 minute period following heparin reversal post-cardiopulmonary bypass (CPB).

  2. Placebo group received normal saline IV following heparin reversal post-CPB.


NB: Both groups were exposed to cell salvage.
Outcomes Number of patients transfused allogeneic blood (n)
Amount of allogeneic blood transfused (units)
Blood loss (mls)
Thrombosis (n)
Re-operation for bleeding (n)
Myocardial infarction (n)
Hypotension (n)
Notes Quality assessment score (Schulz criteria): 3/7
Transfusion protocol not described.
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Method of randomisation was not described.
Allocation concealment? No C - Inadequate.
Blinding?
All outcomes		 Yes Double blind.