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. Author manuscript; available in PMC: 2014 Oct 29.
Published in final edited form as: Cochrane Database Syst Rev. 2004;(1):CD001884. doi: 10.1002/14651858.CD001884.pub2
Methods Methods of randomisation and allocation concealment were not described
Participants 27 patients undergoing elective myocardial revascularisation or single-valve replacement surgery were randomised to one of two groups

  1. Desmopressin (DDAVP) group: n = 14; M/F = 12/2; mean age (+/−SD) = 60 (16) years.

  2. Placebo group: n = 13; M/F = 9/4; mean age (+/−SD) = 55 (15) years.
Interventions

  1. DDAVP group received 0.3 ug/kg of intravenous DDAVP administered over a 10-minute interval by an infusion pump, commencing 15 minutes after the completion of the protamine dose.

  2. Placebo group received an equal volume of saline solution intravenously administered over a 10-minute interval by an infusion pump, commencing 15 minutes after the completion of the protamine dose


NB: Both groups were exposed to cell salvage (Haemonetics) in the pre-and post-CPB periods
Outcomes Amount of allogeneic blood transfused (units)
Blood loss (ml)
Hypotension (n)
Notes Quality assessment score (Schulz criteria): 4/7
Transfusion protocol not specified.
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Method of randomisation was not described.
Allocation concealment? Unclear B - Unclear
Blinding?
All outcomes		 Yes Double blind.