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. Author manuscript; available in PMC: 2014 Oct 29.
Published in final edited form as: Cochrane Database Syst Rev. 2004;(1):CD001884. doi: 10.1002/14651858.CD001884.pub2
Methods Method of randomisation and allocation concealment was not described
Participants 44 patients who had taken acetylsalicylic acid within 7 days of scheduled coronary bypass surgery were randomly assigned to one of two groups:
  1. Desmopressin (DDAVP) group: n = 20; M = 20; mean age = 56.6 years (range, 52.9-60.3)

  2. Placebo group: n = 24; M = 24; mean age = 61.6 years (range, 58.6-64.6)

Interventions
  1. DDAVP group received 10 ug of DDAVP per/metre squared (body surface area) diluted in saline, infused intravenously over 20 minutes after the completion of cardiopulmonary bypass and reversal of heparinisation.

  2. Placebo group received equivalent volumes of saline.

Outcomes Number of patients transfused allogeneic blood (n)
Amount of allogeneic blood transfused (units)
Number of patients transfused fresh frozen plasma (n)
Number of patients transfused platelets (n)
Blood loss (mls)
Mortality (n)
Stroke (n)
Notes Quality assessment score (Schulz criteria): 4/7
Transfusion protocol not specified.
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Method of randomisation was not described.
Allocation concealment? Unclear B - Unclear
Blinding?
All outcomes
Yes Double blind.