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. Author manuscript; available in PMC: 2014 Oct 29.
Published in final edited form as: Cochrane Database Syst Rev. 2004;(1):CD001884. doi: 10.1002/14651858.CD001884.pub2

Comparison 1. Desmopressin versus control (blood transfused and blood loss).

Outcome or subgroup title No. of
studies
No. of
participants
Statistical method Effect size
1 No. exposed to allogeneic blood
- All studies
19 1387 Risk Ratio (M-H, Random, 95% CI) 0.96 [0.87, 1.06]
2 No. exposed to allogeneic blood
- Type of surgery
19 1387 Risk Ratio (M-H, Random, 95% CI) 0.96 [0.87, 1.06]
2.1 Cardiac 15 1196 Risk Ratio (M-H, Random, 95% CI) 0.95 [0.84, 1.07]
2.2 Miscellaneous 4 191 Risk Ratio (M-H, Random, 95% CI) 1.01 [0.81, 1.26]
3 No. exposed to allogeneic blood
- Cardiac surgery
15 1196 Risk Ratio (M-H, Random, 95% CI) 0.95 [0.84, 1.07]
3.1 Primary CABG surgery 9 586 Risk Ratio (M-H, Random, 95% CI) 0.85 [0.73, 0.99]
3.2 CABG + valve +/−
combination / redo surgery
6 610 Risk Ratio (M-H, Random, 95% CI) 1.03 [0.88, 1.19]
4 No. exposed to allogeneic blood
- Cardiac surgery - ASA use
10 685 Risk Ratio (M-H, Random, 95% CI) 0.84 [0.69, 1.01]
4.1 ASA use within 7 days
prior to surgery
6 399 Risk Ratio (M-H, Random, 95% CI) 0.89 [0.64, 1.23]
4.2 No ASA use within 7 days
of surgery
4 286 Risk Ratio (M-H, Random, 95% CI) 0.79 [0.62, 1.01]
5 No. exposed to allogeneic blood
- Transfusion protocol
19 1387 Risk Ratio (M-H, Random, 95% CI) 0.96 [0.87, 1.06]
5.1 Transfusion Protocol 10 736 Risk Ratio (M-H, Random, 95% CI) 0.90 [0.77, 1.04]
5.2 No Transfusion Protocol 9 651 Risk Ratio (M-H, Random, 95% CI) 1.03 [0.93, 1.14]
6 No. exposed to allogeneic blood
- Use of autologous techniques (ANH, PAD, CS)
19 1387 Risk Ratio (M-H, Random, 95% CI) 0.96 [0.87, 1.06]
6.1 No autologous techniques
used
10 732 Risk Ratio (M-H, Random, 95% CI) 0.91 [0.78, 1.07]
6.2 Autologous technique/s
used (ANH, PAD, CS)
9 655 Risk Ratio (M-H, Random, 95% CI) 1.00 [0.84, 1.19]
7 Trial quality - Allocation concealment (Cochrane scale) 19 1387 Risk Ratio (M-H, Random, 95% CI) 0.96 [0.87, 1.06]
7.1 Quality A 3 249 Risk Ratio (M-H, Random, 95% CI) 0.97 [0.75, 1.24]
7.2 Quality B 11 766 Risk Ratio (M-H, Random, 95% CI) 0.88 [0.75, 1.03]
7.3 Quality C 5 372 Risk Ratio (M-H, Random, 95% CI) 1.11 [0.94, 1.33]
8 Units of blood transfused - All
patients
14 885 Mean Difference (IV, Random, 95% CI) −0.30 [−0.60, −0.01]
9 Units of blood transfused - Type
of surgery
14 885 Mean Difference (IV, Random, 95% CI) −0.30 [−0.60, −0.01]
9.1 Cardiac 10 621 Mean Difference (IV, Random, 95% CI) −0.39 [−0.77, −0.01]
9.2 Orthopaedic 2 129 Mean Difference (IV, Random, 95% CI) −0.15 [−0.64, 0.33]
9.3 Vascular 2 135 Mean Difference (IV, Random, 95% CI) 0.06 [−0.89, 1.02]
10 Units of blood transfused - All
patients - Use of autologous
techniques (ANH, PAD, CS)
14 885 Mean Difference (IV, Random, 95% CI) −0.30 [−0.60, −0.01]
10.1 No autologous
techniques used
10 734 Mean Difference (IV, Random, 95% CI) −0.22 [−0.55, 0.10]
10.2 Autologous technique/s
used (ANH, PAD, CS)
4 151 Mean Difference (IV, Random, 95% CI) −0.47 [−1.15, 0.20]
11 Units of blood transfused - In
those transfused
5 211 Mean Difference (IV, Random, 95% CI) −0.49 [−0.94, −0.04]
12 Blood loss - All surgery 22 2363 Mean Difference (IV, Random, 95% CI) −113.05 [−160.27, −
65.84]
12.1 Intra-operative blood
loss
7 493 Mean Difference (IV, Random, 95% CI) −90.07 [−199.56, 19.
42]
12.2 Post-operative blood loss 18 1201 Mean Difference (IV, Random, 95% CI) −92.98 [−149.86, −
36.11]
12.3 Total blood loss -
intra+post-operative blood loss
10 669 Mean Difference (IV, Random, 95% CI) −241.78 [−387.55, −
96.01]
13 Blood loss - All surgery (time
period)
22 Mean Difference (IV, Random, 95% CI) Subtotals only
13.1 Intra-operative blood
loss
7 493 Mean Difference (IV, Random, 95% CI) −90.07 [−199.56, 19.
42]
13.2 0-6 hours post-operative
blood loss
1 59 Mean Difference (IV, Random, 95% CI) −98.0 [−304.99, 108.
99]
13.3 0-12 hours post
operative blood loss
3 233 Mean Difference (IV, Random, 95% CI) −114.05 [−269.46,
41.36]
13.4 0-16 hours post
operative blood loss
2 122 Mean Difference (IV, Random, 95% CI) −18.01 [−113.34, 77.
32]
13.5 0-24 hours post
operative blood loss
12 787 Mean Difference (IV, Random, 95% CI) −100.41 [−176.48, −
24.34]
13.6 Total blood loss -
intra+post-operative blood loss
10 669 Mean Difference (IV, Random, 95% CI) −239.02 [−388.58, −
89.46]
14 Blood loss - Cardiac surgery 18 1832 Mean Difference (IV, Random, 95% CI) −116.81 [−172.63, −
60.99]
14.1 Intra-operative blood
loss
3 229 Mean Difference (IV, Random, 95% CI) −119.79 [−314.57,
75.00]
14.2 Post-operative blood loss 16 1107 Mean Difference (IV, Random, 95% CI) −96.58 [−163.04, −
30.12]
14.3 Total blood loss -
intra+post-operative
7 496 Mean Difference (IV, Random, 95% CI) −237.92 [−413.43, −
62.40]
15 Blood loss (Post-operative) -
Cardiac surgery - ASA use
13 854 Mean Difference (IV, Random, 95% CI) −108.10 [−175.60, −
40.60]
15.1 ASA use within 7 days
prior to surgery
10 633 Mean Difference (IV, Random, 95% CI) −109.57 [−200.11, −
19.03]
15.2 No ASA use within 7
days of surgery
3 221 Mean Difference (IV, Random, 95% CI) −112.69 [−227.59, 2.
22]
16 Blood loss - Cardiac surgery
(time period)
18 Mean Difference (IV, Random, 95% CI) Subtotals only
16.1 Intra-operative blood
loss
3 229 Mean Difference (IV, Random, 95% CI) −119.79 [−314.57,
75.00]
16.2 0-6 hours post-operative
blood loss
1 59 Mean Difference (IV, Random, 95% CI) −98.0 [−304.99, 108.
99]
16.3 0-12 hours post
operative blood loss
3 233 Mean Difference (IV, Random, 95% CI) −114.05 [−269.46,
41.36]
16.4 0-16 hours post
operative blood loss
2 122 Mean Difference (IV, Random, 95% CI) −18.01 [−113.34, 77. 32]
16.5 0-24 hours post
operative blood loss
10 693 Mean Difference (IV, Random, 95% CI) −107.46 [−207.12, −
7.80]
16.6 Total blood loss -
intra+post-operative blood loss
7 496 Mean Difference (IV, Random, 95% CI) −237.92 [−413.43, −
62.40]
17 Blood loss - Post-operative
blood loss by CPB times
15 1024 Mean Difference (IV, Random, 95% CI) −93.34 [−162.24, −
24.44]
17.1 Less than 80 minutes 3 198 Mean Difference (IV, Random, 95% CI) −41.22 [−157.25, 74.
80]
17.2 Between 80-100 minutes 5 330 Mean Difference (IV, Random, 95% CI) −104.18 [−184.75, −
23.61]
17.3 Between 101-120
minutes
3 129 Mean Difference (IV, Random, 95% CI) 53.08 [−156.33, 262.
50]
17.4 Between 121-140
minutes
2 196 Mean Difference (IV, Random, 95% CI) −46.53 [−366.29,
273.23]
17.5 Greater than 140
minutes
2 171 Mean Difference (IV, Random, 95% CI) −344.74 [−478.50, −
210.97]