Fig. 8.

ROC analyses of three measures of protein similarity. We compare the effectiveness of sequence only (compared with FASTA), 3D sequence traces (compared with STRUCTAL), and 3D structures (compared with STRUCTAL) to detect fold similarity in a set of 605 proteins. “True” relationships are defined by CATH topologies. Curves close to the first diagonal (such as the ROC curve for FASTA) indicate poor performance, while the upper most curve (such as the 3D structure-based curve) indicates good performance.