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. 2014 Jan 13;1(2):107–114. doi: 10.1002/acn3.30

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© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Decreased fractional anisotropy (FA), decreased N-acetylaspartate (NAA), increased myo-inositol (mI), and decreased γ-aminobutyric acid (GABA) levels in amyotrophic lateral sclerosis (ALS) patients. Circles represent respective values of FA in the corticospinal tract (A), NAA in the left motor cortex (B), mI in the left motor cortex (C), and GABA levels in the left motor cortex (D) for individual ALS patients and healthy controls (HC). Horizontal bars indicate the mean. IU, institutional units.