Table 2.
Additional GSL tested for stimulation of XV19 hybridoma cells.
| No. | Trivial name | Structure | Ceramidea) | Effectb) | Source |
|---|---|---|---|---|---|
| 1. | GlcCer | Glcβ1Cer | d18:1/t18:0–16:0–24:0c)d) | − | Porcine kidney |
| 2. | GalCer | Galβ1Cer | D18:1-h18:0-h24:0d | − | Sigma |
| 3. | LacCer | Galβ4Glcβ1Cer | d18:1–16:0 and 24:1e) | − | Human neutrophils |
| 4. | Sulf-LacCer | SO3-3Galβ4Glcβ1Cer | D18:1-h16:0-h24:0d) | − | Human kidney |
| 5. | Galabiaosyl | Galα4Galβ1Cer | d18:1–16:0–24:0d) | − | Human kidney |
| 6. | GM4 | NeuAcα3Galβ1Cer | D18:1/d20:1–18:0c) | − | Human brain |
| 7. | Globotri (Gb3) | Galα4Galβ4Glcβ1Cer | d18:1–16:0 and 24:0e) | − | Human erythrocytes |
| 8. | Isoglobotri (iGb3) | Galα3Galβ4Glcβ1Cer | t18:0-h22:0 and h24: e) | − | Cat intestine |
| 9. | GM3 | NeuAcα3Galβ4Glcβ1Cer | d18:1/d20:1–18:0c) | − | Human brain |
| 10. | GM1 | Galβ3GalNAcβ4(NeuAcα3)Galβ4Glcβ1Cer | d18:1/d20:1–18:0c) | − | Human brain |
In the shorthand nomenclature for fatty acids and bases, the number before the colon refers to the carbon chain length and the number after the colon gives the total number of double bonds in the molecule. For long chain bases, d denotes dihydroxy and t denotes trihydroxy. Thus, d18:1 designates sphingosine (1,3-dihydroxy-2-aminooctadecene) and tl8:0 phytosphingosine (l,3,4-trihydroxy-2-aminooctadecane). Fatty acids with a 2-hydroxy group are denoted by the prefix h before the abbreviation e.g. h16:0.
Summary of the relative stimulatory effect in the assays with different APC and XV19 hybridoma responder cells (see also Table 1).
The GSL contains isoforms differing in the long chain base.
The fatty acid of the GSL varies in length between the indicated numbers.
The fatty acid of the GSL has two dominant lengths as indicated.