Table 2.
Effects of the aqueous extract of F. glumosa on saluretic and natriuretic activity from 24 h of urine.
| Drugs (mg/kg) | Saluretic | Natriuretic | CAI | Saluretic index | Natriuretic index | CAI index |
|---|---|---|---|---|---|---|
| (Na+ + Cl−) | (Na+/k+) | Cl/(Na + K) | ||||
| Control | 33.39 ± 3.12 | 0.93 ± 1.18 | 0.45 ± 0.67 | 1.00 | 1.00 | 1.00 |
| Extract | ||||||
| 225 | 104.79 ± 4.28∗∗∗ | 1.43 ± 1.40∗ | 0.48 ± 0.50∗ | 3.13 | 1.53 | 1.07 |
| 300 | 205.51 ± 2.29∗∗∗ | 1.92 ± 1.75∗∗ | 0.64 ± 0.44∗∗ | 6.15 | 2.06 | 1.42 |
| 375 | 304.67 ± 3.34∗∗∗ | 3.33 ± 0.80∗∗∗ | 0.75 ± 0.42∗∗ | 9.12 | 3.58 | 1.66 |
| Furosemide (2 mg/kg) | 187.99 ± 12.67∗∗∗ | 2.65 ± 2.45∗∗∗ | 0.70 ± 0.49∗∗ | 5.63 | 2.85 | 1.55 |
| Amiloride H. (14 mg/kg) | 147.64 ± 4.80∗∗∗ | 2.95 ± 2.68∗∗∗ | 0.48 ± 0.50∗∗ | 4.42 | 3.17 | 1.07 |
Values are means ± SEM, n = 5, ∗ < 0.05, ∗∗ < 0.01, and ∗∗∗ < 0.001, significant difference compared to the control.
CAI: carbonic anhydrase inhibition;
saluretic index: saluretic activity in test group/saluretic activity in control group;
natriuretic index: natriuretic activity in test group/natriuretic activity in control group;
carbonic anhydrase inhibition index: CAI activity in test group/CAI activity in control group.