Table 7.

Drug release kinetics for different formulations.

Kinetic Model	Parameters	Formulation code
		G-1	G-2	G-3	G-4	G-5	G-6	G-7	G-8	G-9
Zero-order	R	0.344	0.403	0.497	0.485	0.647	0.533	0.467	0.617	0.355
	RSS	9221	7800	6307	5485	3925	6721	7536	5095	7632
	K 0	7.394	6.989	6.627	6.11	5.775	7.045	7.197	6.335	6.996
First-order	R	0.942	0.910	0.916	0.865	0.925	0.965	0.963	0.915	0.944
	RSS	0.893	1351	1271	1657	1175	653	685	1055	1287
	K 1	−0.204	−0.169	−0.145	−0.115	0.107	−0.176	−0.197	−0.123	−0.162
Higuchi	R	0.915	0.927	0.943	0.947	0.965	0.956	0.945	0.962	0.934
	RSS	1637	1304	849	797	434	8.203	997	629	1092
	k H	27.344	25.747	24.336	22.457	21.001	25.813	26.433	23.102	25.794
Hixon-Crowell	R	0.846	0.816	0.823	0.785	0.853	0.897	0.886	0.844	0.846
	RSS	2672	2813	2404	2570	1842	1922	2125	1952	2726
	k HC	−0.042	−0.034	−0.037	−0.033	−0.025	−0.043	−0.046	−0.035	−0.035
Peppas and Korsmeyer	R	0.922	0.926	0.957	0.935	0.945	0.963	0.955	0.956	0.954
	RSS	11.836	959	584	642	472	504	552	683	417
	k	32.131	2991	28.183	25.123	21.366	30.165	32.065	23.482	33.812
	n	0.443	0.445	0.445	0.465	0.503	0.445	0.423	0.505	0.393
Best fit model		FO	M	PK	M	M	FO	FO	M	PK

RSS = Residual sum of squares

k = Release constant

n = Diffusion coefficient

ZO = Zero order

FO = First order

H = Higuchi

PK = Peppas Korsmeyer.