Table 3.
Multivariable modeling
| Renal composite | ESRD | |
|---|---|---|
| HR (95% CI) | HR (95% CI) | |
| Unadjusted | 1.28 (1.15 to 1.43) | 1.83 (1.56 to 2.13) |
| Model 1 adjusted for age, sex, and race | 1.30 (1.16 to 1.45) | 1.62 (1.38 to 1.90) |
| Model 2 model 1+proteinuria | 1.07 (0.96 to 1.21) | 1.23 (1.05 to 1.45) |
| Model 3 model 2+ eGFR | 1.05 (0.94 to 1.18) | 1.18 (1.01 to 1.38) |
| Model 4 model 3+SBP and history of HTN | 1.06 (0.94 to 1.18) | 1.16 (0.99 to 1.37) |
| Model 5 model 4+known duration of diabetes, HbA1c, and insulin use | 1.00 (0.88 to 1.23) | 1.09 (0.92 to 1.29) |
| Model 6 model 5+smoking status, CAD, atrial fibrillation, ACE/ARB use, aldosterone inhibitor use, total cholesterol, CRP, and treatment with darbepoetin | 1.06 (0.93 to 1.20) | 1.12 (0.94 to 1.32) |
ARB, angiotensin receptor blocker; CAD, coronary artery disease; CRP, C reactive protein; eGFR, estimated glomerular filtration rate; HbA1c, glycosylated hemoglobin; HTN, hypertension; SBP, systolic blood pressure.