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. Author manuscript; available in PMC: 2015 Mar 18.
Published in final edited form as: Nat Commun. 2014 Sep 18;5:4954. doi: 10.1038/ncomms5954

Figure 3. De novo TBR1 truncating mutations abolish transcriptional repression activity.

Figure 3

Luciferase reporter assays for transcriptional regulatory activity of TBR1 variants in HEK293 cells. Values are expressed relative to the control. (***P<0.001, **P<0.01; NS, not significant when compared with WT TBR1). The mean±s.e.m. of three independent experiments performed in triplicate is shown.