Figure 1. Adjusted Hazard Ratios (95% Confidence Intervals) for baseline Fructosamine, Glycated Albumin, and Hemoglobin A1c with incident Chronic Kidney Disease and Incident Diabetes.

Legend: Adjusted hazard ratios are from Cox proportional hazards models with adjustment for age (years), race-center, sex (male, female), body mass index (kg/m²), (body mass index)². Baseline fructosamine, glycated albumin, and hemoglobin A1c were modeled using restricted cubic splines (solid lines) with knots at the 5^th, 35^th, 65^th, and 95^th percentiles. All models are centered at the 50^th percentile (fructosamine: 228 umol/L, glycated albumin: 12.7%, hemoglobin A1c: 5.4%). The shaded areas are the confidence intervals for the restricted cubic spline models. Models are truncated at the 5^th and 95^th percentile of each marker, histograms are truncated at the 1^st and 99^th percentile. For incident chronic kidney disease, baseline study population was limited to persons with normal kidney function (estimated glomerular filtration rate ≥60 ml/min/1.73 m²), N=11,932. For incident diabetes, baseline study population was limited to persons without a history of diabetes, N=10,946.