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. 2014 Sep 15;8(10):10826–10836. doi: 10.1021/nn504636n

Figure 3.

Figure 3

Compatibilities of MTNs. (a) Evaluation of platelet adhesion on vWf and MTN/vWF surfaces via LDH assays (at 490 nm). (b) Flow cytometry analysis of platelet activation after incubating with two different substrate coatings by the expression of CD62(+) and PAC-1. * represents p < 0.05 vs vWF. (c1) SEM image of platelet adhering on the vWF surface. A severe aggregation was observed. (c2) Platelet adhering on MTN-coated vWF surface. Fewer platelets (circled) remained and less activation reaction was observed. (d) Cytocompatibility study of MTNs compared to control NPs. Both groups possess >90% cell viability up to 1000 μg/mL. N = 3–5.