Skip to main content
. Author manuscript; available in PMC: 2014 Oct 29.
Published in final edited form as: Subcell Biochem. 2013;66:267–295. doi: 10.1007/978-94-007-5940-4_10

Fig. 10.5. Overview of the Pup-proteasome system in mycobacteria.

Fig. 10.5

Pup is deamidated at the C-terminal Gln by Dop. PafA phosphorylates the α-carboxylate of the C-terminal Glu of Pup, priming it for attack by the ε-amino group of a substrate Lys. Pup can be removed by Dop prior to degradation to potentially rescue a substrate from destruction or possibly facilitate its degradation