. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: J Pediatr Gastroenterol Nutr. 2014 Apr;58(4):443–448. doi: 10.1097/MPG.0000000000000272

Table 3.

Fat soluble vitamin status as mean ± SD, or median [range] from previous and current studies in children with CF and PI

	CF Nutrition^a	CF Bones^b	CF Avanti
Study Years	1998–2000	2000–2002	2007–2010
CF Centers, n	13	3	9
Sample size, n^c	78	101	58
Age, yrs	7.3 ± 0.9	14.8 ± 4.2	10.3 ± 2.9
Range	6.0 – 10.0	8.0 – 25.0	5.0 – 17.9
Vitamin A, ug/mL
Mean	52.0 ± 13.0	82.0 ± 29.0	38.0 ± 12.0
Median	–	80 [33.0 – 208.0]	38.0 [12.9 – 89.6]
Low status (<30 ug/dL), %	4	0	20
Vitamin D, ng/mL
Mean	42.6 ± 12.2^d	20.7 ± 6.5	32.0 ± 8.2
Median	40.0 [18.9 – 79.2]^d	20.3 [4.5 – 34.9]^d	31.2 [9.3 – 77.0]
Low status (<30ng/mL), %	12	90	50
Vitamin E,
αTocopherol:Cholesterol ratio
Mean	8.8 ± 3.4^d	11.4 ± 5.5^d	8.2 ± 2.2
Median	8.2 [2.9 – 20.2]	10.7 [2.9 – 27.3]^d	7.7 [2.4 ± 15.5]
Low status (<5.4 mg/g), %	13	13	13
Vitamin K,
% ucOC
Mean	–	33.7 ± 17.9^d	28.7 ± 11.5
Median	–	34.6 [3.1 – 76.1]	25.3 [3.8 – 99.3]
Low status (>50%), %		19	5
PIVKA II, ng/mL
Mean	–	4.6 ± 6.5^d	1.3 ± 0.7
Median	–	2.1 [0 – 41.6]	1.2 [0.3 – 16.7]
Low status (>2.0 ng/mL), %		50	19

References #11, #12;

References #10, #13, #14;

sample size for each vitamin may be smaller based on number of completed assays;

unpublished data