Table 1.

Serial Changes of BP, Inflammatory Biomarkers and Combined End-Points at 72 Hours after CLP

Variables	Group 1 (n=10)	Group 2 (n=10)	Group 3 (n=10)	Group 4 (n=10)	Group 5 (n=10)	p-value
Mortality	0% (0)	40% (4)	30% (3)	10% (1)	20% (2)	0.181
Dark bloody ascites*	0% (0)	40% (4)	20% (2)	10% (1)	10% (1)	0.230
Combined end-point†	0% (0)a	60% (6)b	30% (3)a	10% (1)a	20% (2)a	0.02
SBP (mmHg) at 0 h	101 ± 8.8	108 ± 12.1	105 ± 9.6	108 ± 9.1	109 ± 8.8	> 0.1
SBP (mmHg) at 28 h	109 ± 8.2	109 ± 21.5	106 ± 20.6	115 ± 16.4	109 ± 16.8	>0.05
WBC (x 103) at 0 h	11.0 ± 1.7	11.2 ± 1.3	11.5 ± 1.9	11.0 ± 3.0	11.4 ± 2.3	>0.5
WBC (x 103) at 6 h	10.0 ± 1.2a	16.5 ±1.2b	15.3 ± 1.1b	13.1 ± 0.9c	13.0 ± 1.9c	<0.001
WBC (x 103) at 72 h	7.9 ± 1.2a	13.0 ± 1.5b	12.5 ± 1.5b	10.3 ± 1.7c	10.9 ± 0.8c	<0.001
IL-6 (pg/mL) at 0 h	6.28 ± 1.49	7.3 ± 2.0	7.0 ± 1.9	7.1 ± 2.4	7.9 ± 1.8	>0.5
IL-6 (pg/mL) at 6 h	9.2 ± 2.9a	182 ± 103b	177 ± 116b	138 ± 61c	140 ± 66c	<0.0001
IL-6 (pg/mL) at 18 h	9.4 ± 2.7a	151 ± 146b	129 ± 26c	90.8 ± 26.2d	87.6 ± 37.7d	<0.0001
Il-6 (pg/mL) at 72 h	6.0 ± 1.0a	95.4 ± 50.8b	70.8 ± 19.4c	58.2 ± 9.8d	66.3 ± 7.5d	<0.0001

Procedure. Data are expressed as mean ± SD or % (n).

^*indicate ≥1.0 cc ascites was collected.

^†defined as mortality or abdominal fluid presented ≥1.0 cc.

CLP=cecal-ligation and puncture; SBP=systolic blood pressure; WBC=white blood cell count; IL=interleukin. Group 1=sham control; Group 2=CLP; Group 3=CLP + melatonin; Group 4=CLP + apoptotic adipose derived mesenchymal stem cell (A-ADMSC); Group 5=CLP + melatonin + A-ADMSC.

^aWithin a row, means without a common letters were different (P<0.05).

^bWithin a row, means without a common letters were different (P<0.05).

^cWithin a row, means without a common letters were different (P<0.05).

^dWithin a row, means without a common letters were different (P<0.05).