Table 2.

Univariate factor analysis of disease free survival and overall survival

Characteristics	No	Disease Free Survival		Overall Survival
		Median (95% CI)	P	Median (95% CI)	P
Gender
Man	15	13.4 (5.0-21.8)	0.76	36.1 (22.1-50.1)	0.60
Woman	13	9.3 (6.2-20.7)		40.5 (22.5-58.5)
Age
<60 y	13	13.2 (3.8-22.5)	0.21	48.0 (20.9-75.2)	0.17
≥60 y	15	13.4 (16.7-46.1)		36.0 (36.1-48.7)
Smoking
Never smoker	17	9.3 (8.4-22.5)	0.74	40.6 (32.6-48.4)	0.88
Smoker	11	13.4 (6.3-20.4)		27.4 (0-70.1)
Histology
Adenocarcinoma	21	13.4 (4.6-22.2)	0.42	48.0 (25.0-71.1)	0.14
Non-adenocarcinoma	7	7.6 (3.3-11.9)		27.4 (15.3-39.4)
Clinical Response
PRa	18	15.4 (10.3-20.5)	0.68	36.1 (3.9-68.3)	0.63
SDb	10	7.4 (3.6- 11.3)		40.5 (31.0-50.0)
Mediastinal downstaging
N0	19	16.3 (7.1-25.5)	0.001	52.8 (14.0-91.4)	0.187
N1 or N2	9	5.3 (4.2-6.5)		36.8 (27.6-46.0)
Islet/stromal macrophage ratio
< median	14	5.5 (4.4-6.6)	0.04	34.8 (21.8-47.9)	<0.01
≥ median	14	20.7 (11.4-30.0)		unreached
Total macrophages
< median	14	33.4 (7.5-59.3)	0.001	36.1 (0-75.4.2)	0.72
≥ median	14	5.5 (4.2-6.7)		36.8 (27.1-46.4)

^aPR: partial response;

^bSD: stable disease.