Figure 2.

(a) Schematic representation of oxazolone-induced colitis model. Female SJL/J mice were sensitized with oxazolone painted on the skin daily for 5 days, then challenged intrarectally with oxazolone daily starting on Day 0. Starting the day before intrarectal challenge (Day −1) and every other day, mice were administered protein therapeutics intraperitoneally. At time of killing on Day 8, colons were excised and length and weight were determined. (b) Disease activity index. The daily clinical assessment was performed after the intrarectal oxazolone challenge. Stool consistency was observed visually and occult/gross bleeding was assessed using the Beckman Coulter occult blood testing kit.