Figure 3.

Gene expression of glial cell marker after pneumococcal meningitis. Analysis of mRNA expression of the astrocyte marker GFAP (a, c) and the activated microglia marker Itgam (b, d) in the hippocampal formation and cortex of formyl peptide receptor 1 knockout (FPR1-KO) or FPR2-KO) and wild-type (WT) mice 30 hr after induction of pneumococcal meningitis by real-time RT-PCR were assessed from six independent experiments in duplicate. The asterisks indicate a significant difference between infected WT and infected FPR1-KO mice as determined by analysis of variance followed by Bonferroni test (*P < 0·05).