Figure 5.

Expression of anti-inflammatory factors and chemokines after pneumococcal meningitis in different brain regions. Thirty hours after subarachnoid infection with Streptococcus pneumoniae, mRNA expression levels of interleukin-1 receptor antagonist (IL-1RA; a, e), haemoxygenase 1 (HO-1; b, f), CCL2 (c, g) and CCL3 (d, h) were determined in the hippocampal formation and cortex of formyl peptide receptor 1 knockout (FPR1-KO) or FPR2-KO and wild-type (WT) mice by real-time RT-PCR. Data were assessed from six independent experiments in duplicate. An asterisk indicates a significant difference between infected WT and infected FPR1-KO or FPR2-KO mice as determined by anova followed by Bonferroni test (*P < 0·05; **P < 0·01).