Table 2.
Bacterial titres after pneumococcal meningitis
| Bacterial titre (log CFU/ml) | ||||
|---|---|---|---|---|
| Cerebellum | Blood | Spleen | ||
| WT | 5 (4·3/5·48) | 5 (3·98/5·4) | 5·9 (5·3/6·3) | |
| FPR1-KO | 8·3 (7/10)** | 7 (7/9)*** | 9·6 (6·6/10·8)*** | |
| FPR2-KO | 5·65 (4·9/8·25) | 5·78 (4·95/7·25)* | 6·65 (5·75/8·9) | |
CFU, colony forming units; FPR, formyl peptide receptor 1; WT, wild-type; KO, knockout.
Data are presented as median (25th/75th centile).
Please note significantly increased bacterial titres in infected FPR1- or 2-KO compared to infected WT mice (n = 9 each group;
*
P = 0·0301 for blood;
**
P = 0·0041 for cerebellum;
***
P = 0·0006 for blood and P = 0·0009 for spleen; Mann–Whitney U-test).