Figure 5. Effect of PASE on aldosterone-induced human mineralocorticoid receptor (hMR) transcriptional activity.

CV-1 cells transfected with hMR expression and MMTV-LUC reporter plasmids were treated with vehicle (V) or aldosterone 1 nM (A1 nM) in presence of spironolactone 100 nM (S100 nM) or PASE 10 nM, 100 nM or 1 µM (P10 nM, P100 nM or P1 µM). Each data point represents the mean ± SEM derived from 3 independent experiments. *p<0.01 vs V; ^†p<0.05 vs. A1 nM.