Table 2. Hemodynamic parameters and collagen content.
| CONTROL | ALDO | PASE | ALDO+PASE | SPIRO | ALDO+SPIRO | |
| SBP (mm Hg) | 119±1.9 | 145±2.4* | 114±4.1† | 119±2.6† | 116±5.4† | 113±2.1† |
| DBP (mm Hg) | 89±1.2 | 108±3.1* | 91±3.4† | 92±4.1† | 83±1.2† | 91±2.2† |
| LVSP (mm Hg) | 121±1.7 | 146±9.3* | 115±2.3† | 123±2.5† | 117±2.3† | 116±1.8† |
| LVEDP (mm Hg) | 3.8±0.2 | 9.7±0.4* | 4±0.5† | 3.1±0.7† | 4.9±1.1† | 3.9±0.6† |
| HR (BPM) | 385±27 | 359±46 | 348±29 | 391±45 | 381±38 | 363±44 |
| +dP/dt (mm Hg/s) | 9390±163 | 8177±236 | 8128±388 | 10065±416† | 8367±325 | 8230±299 |
| –dP/dt (mm Hg/s) | −7106±479 | −4859±398* | −6125±356† | −9789±301† | −5988±196† | −6020±241† |
| HW/BW (mg/g) | 2.8±0.6 | 3.1±0.12* | 2.6±0.06† | 2.7±0.1† | 2.4±0.2† | 2.5±0.1† |
| COLLAGEN (%) | 0.057±0.01 | 0.220±0.02* | 0.065±0.01† | 0.051±0.02† | 0.042±0.02† | 0.065±0.01† |
SBP, systolic blood pressure; DBP, diastolic blood pressure; LVEDP, left ventricular end-diastolic pressure; LVSP, left ventricular systolic pressure, HR, heart rate; +dP/dt the first derivative of LV pressure rise over time; –dP/dt, the first derivative of LV pressure decline over time. HW/BW; heart weight/100 g body weight.
*p<0.05 vs CONTROL;
†
p<0.05 vs ALDO.